University of Oregon biologists have uncovered a mechanism by which a well-known breast cancer gene also influences fertility. Mutations in the BRCA1 gene sharply increase a person's risk of ...

A study led by Harvard Medical School researchers shed new light on how even a single defective copy of the tumor-suppressor BRCA1 gene can increase patients’ risk of developing breast cancer.

Harmful variants in the BRCA1 gene greatly increase a person's lifetime risk of developing breast, ovarian and pancreatic cancers, but most people are unaware they are carriers. In a new study in the ...

Mutations in the BRCA1 gene that are either inherited (germline) or acquired (somatic) might not be key to the initiation of prostate cancer, as previously thought, suggests the first study of its ...

Researchers at LUMC have made a breakthrough in understanding PALB2 mutations, an important cause of hereditary breast cancer. By identifying which mutations affect the function of PALB2, doctors can ...