The lab of Filippo Veglia, Ph.D., at The Wistar Institute has discovered a previously unknown mechanism for how aggressive brain cancers reprogram immune system cells from fighting cancer to enabling ...

FAS, fatty acid synthase; FATP, fatty acid transporter protein; GPCR, G protein-coupled receptor; LPC, lysophosphatidylcholine; LXR, liver X receptor; PPARγ, peroxisome proliferator-activated receptor ...

Tumor growth unfolds within a tumor microenvironment (TME) defined by metabolic–immune crosstalk. Emerging evidence indicates that cancer cells not only reprogram glycolysis but also alter amino acid, ...

For many families, the most shocking part of a cancer journey is not the tumour itself, but the steady wasting that follows — loss of appetite, falling weight, thinning muscles, and the feeling that ...

A mechanism underlying neutrophil reprogramming in brain cancers has been uncovered, illuminating potential therapeutic targets to stop their pro-cancer effect. Tumor-infiltrating neutrophils are ...

A new technology that uses clinical MRI machines to image metabolic activity in the brain could give researchers and clinicians unique insight into brain function and disease, researchers at the ...

Solid tumors often provide a challenging environment for the T cells of our immune system. By reprogramming the metabolism of ...

Researchers have uncovered how metabolic reprogramming contributes to renal fibrosis in IgG4-related disease (IgG4-RD), a systemic immune-mediated disorder. The review, published in a leading journal, ...