A chemical buffer is a solution that can resist changes in pH when small amounts of acid or base are added. Generally, biological compounds with ionizable groups with a pKa around 8 exhibit buffering ...

Students often struggle with the difference between a solution that is buffered and one that is not. This demonstration clearly distinguishes between the two, both qualitatively and quantitatively. It ...

This lab includes the complete titration procedure used to investigate how well a buffer resists changes in pH. Prepare a buffer solution by accurately calculating and measuring the required amounts ...

Biopharmaceutical production depends on buffers. Making sure the right buffer solutions are available, in the right place on the manufacturing line, at the right time, and in the right quantity, is a ...

In this installment, I primarily discuss considerations to keep in mind when choosing buffering additives that will be used for LC methods involving UV absorbance detection. Buffered solutions that ...

In-line buffer management markedly reduced the production bottlenecks and manufacturing costs inherent in biopharmaceutical manufacturing. Additional cost reductions are possible, however, by ...