Understanding how cells transform into specialized types during human development is a central challenge in biology. This complex process, known as cell differentiation, holds the key to understanding ...

Explore scalable strategies for iPSC-derived islet differentiation using GMP-grade activin A and KGF to advance diabetes therapeutics.

In two published papers, researchers at Sylvester Comprehensive Cancer Center, part of the University of Miami Miller School of Medicine, documented their use of a new RNA sequencing technology to ...

For stem cells to differentiate into the appropriate cell-type, transcription factors (TFs) must be tailored to highly specific expression patterns of lineage-specific genes. Abnormalities in the ...

Researchers at the CiRA Foundation in Kyoto, Japan, have published a detailed study [1] showing how carefully defined culture ...

In experiments with mice, Johns Hopkins Medicine scientists report new evidence that precursors of myelin-producing cells—one ...

The Notch signaling pathway plays a pivotal role in determining cell fate, especially in the development and function of T cells. But mimicking this highly mechanical, contact-dependent pathway in the ...

In experiments with mice, Johns Hopkins Medicine scientists report new evidence that precursors of myelin-producing cells — one of the few brain cell types that continue to be produced in the adult ...

Glucose is life's main energy source. But a new study reveals a surprising role as a master manipulator of tissue maturation, hinting at its importance in diabetes and cancer. The sugar glucose, which ...