Cluster randomized trials (CRTs) represent a pivotal design in evaluating public health and clinical interventions where individuals are grouped into clusters (such as schools, hospitals or ...

Background: The provision of nutritional support for patients in intensive care units (ICUs) varies widely both within and between institutions. We tested the hypothesis that evidence-based algorithms ...

Background: Following surgery for rectal cancer, two unfortunate outcomes for patients are permanent colostomy and local recurrence of cancer. We tested whether a quality-improvement strategy to ...

In an open-label, two-period, two-sequence, cross-sectional, cluster-randomized, crossover trial, we assigned hospitals in Ontario, Canada, to use either lactated Ringer’s solution or normal saline ...