For decades, a transcription factor known as STAT3 has been a major therapeutic target in the treatment of cancer. But STAT3 has largely been considered "undruggable" due to the difficulty of ...

People who carry the APOE4 genetic variant face a substantial risk for developing Alzheimer's disease. Now, researchers at Washington University School of Medicine in St. Louis have identified a ...

In this Interview, NewsMedical speaks with Amy Landreman about NanoBRET® Technology and its role in cellular target engagement. Could you start by explaining the significance of understanding cellular ...

A series of preclinical studies show that a new compound, SHP1705, targets circadian clock proteins hijacked by glioblastoma stem cells, impairing the cancer cells’ ability to survive and grow.

Animals house thousands of commensal bacterial species in their guts, which play an important role in maintaining the host’s health. 1 However, antibiotic treatment indiscriminately wipes out both ...