Machine learning models reveal that histone marks are predictive of gene expression across human cell types and highlight important nuances between natural control and the effects of CRISPR-Cas9-based ...

This study presents SynaptoGen, a differentiable extension of connectome models that links gene expression, protein-protein interaction probabilities, synaptic multiplicity, and synaptic weights, and ...

We know the genes, but not their functions." To resolve this long-standing bottleneck in microbial research, a joint research team has proposed a ...

Tsukuba, Japan—Understanding the 3D spatial distribution of gene expression—in which a gene is active or inactive within biological tissue—is essential for uncovering gene functions. One method for ...

We know the genes, but not their functions—to resolve this long-standing bottleneck in microbial research, a joint research ...

Traditionally, cancer diagnosis and prognosis rely heavily on histopathological examination, where tissue morphology is evaluated under the microscope. However, the molecular ...

A recent study marks the first reported instance of generative AI designing synthetic molecules that can successfully control gene expression in healthy mammalian cells. As a proof-of-concept, the ...

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Researchers have developed 'tomoseqr' -- a new software tool that enables easy estimation of the three-dimensional (3D) spatial distribution of gene expression. Tomoseqr is free to use and has been ...