Intermediate filaments (IFs) are critical parts of the structure of cells. They are essential for both normal tissue structure and function. Enabling cells to withstand the stretch and pressure on the ...

Type 3 secretion systems (T3SSs) of bacterial pathogens translocate bacterial effector proteins that mediate disease into the eukaryotic cytosol. Effectors traverse the plasma membrane through a ...

A number of spontaneous mutations in GFAP, encoding an astrocyte-specific intermediate filament protein, causes a neurodegenerative disease. It seems probable that these mutations effect gain of ...

Living cells are constantly exposed to a wide variety of mechanical stresses: heart and lungs must withstand expansion and contraction; our skin must be resistant to tearing whilst retaining ...

Biologists have found a unique version of a filament-forming protein in human cells that insects lack. Providing structural support and protection against such conditions as blistering, cataracts and ...