Intermediate filaments (IFs) are critical parts of the structure of cells. They are essential for both normal tissue structure and function. Enabling cells to withstand the stretch and pressure on the ...

A number of spontaneous mutations in GFAP, encoding an astrocyte-specific intermediate filament protein, causes a neurodegenerative disease. It seems probable that these mutations effect gain of ...

Maintaining the shape of the cell, creating proper internal structure, guiding organelles and pulling chromosomes apart during mitosis are some of the important functions of the cytoskeleton. The ...