As microscopes have improved, so too has their resolution and their ability to image cellular substructure, even down to the single-molecule level. Researchers can now investigate the carefully ...

Space to play or pause, M to mute, left and right arrows to seek, up and down arrows for volume. Dutch scientist Antony van Leeuwenhoek is credited with inventing the light or optical microscope ...

By combining two fundamentally different microscopy techniques, researchers can now measure the optical properties of a ...

Light-sheet microscopy has emerged as a transformative imaging modality that enables rapid, three‐dimensional visualisation of biological specimens with minimal photodamage. By illuminating samples ...

Scientists can now use super-resolution microscopy to directly observe living subcellular structures and activities. In this piece, we explore the basics of three popular super-resolution techniques.

Light microscopy is a cornerstone in life sciences technology, having experienced considerable diversification since its inception. This development becomes visible when considering the distinctive ...

Light field microscopy (LFM) is an advanced imaging technique that captures four-dimensional light information—comprising both spatial and angular data—to computationally reconstruct three-dimensional ...

Light field microscopy was first introduced in 2006, and allows users to capture the 4D light field within the microscope, resulting in 3D volumetric imaging with a single snapshot. Data from light ...

Confocal microscopy is a specialized fluorescence imaging technique that scientists use to acquire images at greater resolution than conventional microscopy. 1 In addition to scanning the lateral x ...

Cells are tiny, so we use microscopes to see their details. A slide is a thin piece of glass used to hold objects which are examined under a microscope. Peel a thin layer of cells from an onion. Place ...