Multiple sequence alignment (MSA) is a cornerstone of computational biology, facilitating the exploration of functional, structural and evolutionary relationships among biological sequences.

The classic methodology of inferring a phylogenetic tree from sequence data is composed of two steps. First, a multiple sequence alignment (MSA) is computed. Then, a tree is reconstructed assuming the ...

Whole genome sequencing (WGS) has the capacity to greatly enhance genomic knowledge and understand mysteries of life by utilizing the most advanced genetic sequencing technologies. WGS can be used for ...

Structural variations (SVs)—large-scale changes in DNA sequence—play a crucial role in shaping traits such as yield, quality, and environmental adaptation in crops.

In the beginning, there was Needleman-Wunsch, which begat Smith-Waterman, which begat FASTA, which begat BLAST, and so on. Peel away the information technology jargon surrounding these alignment ...

Structural variations (SVs), including insertions, deletions, inversions, and substitutions, can profoundly influence gene ...