Retroviral integration into host cell chromosomes was once thought to be random, but new evidence suggests that human immunodeficiency virus preferentially enters the neighborhood of activated genes.

Foamy viruses (FVs) or spumaviruses are retroviruses that have been developed as vectors, but their integration patterns have not been described. We have performed a large-scale analysis of FV ...

Even before we knew what retroviruses were we knew they could induce malignancy. 2 We now know that a number of them are directly associated with cell transformation through mechanisms such as ...

The location of integration of a gene therapy has been crucial for the safety and efficacy of the treatment to cure infants with X-linked severe combined immunodeficiency. Identified integrome ...

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