After transcription, tRNA precursors undergo a multi-step maturation process, including modifications of the nucleotides, 5′ end and 3′ end processing and folding into the L-shaped tertiary structure ...

A groundbreaking study has shed light on the critical role of a tRNA methylation enzyme, TRMT10A, in supporting brain function. The findings reveal how the absence of TRMT10A leads to a reduction in ...

Peer ReviewDownload a summary of the editorial decision process including editorial decision letters, reviewer comments and author responses to feedback. The tRNA methyltransferase family has expanded ...

New findings indicate that transfer RNA (tRNA) has another function in addition to its long-established role in gene expression. tRNA also helps control apoptosis, or programmed cell death, according ...

tRNAs have a distinct cloverleaf secondary structure and an L-shaped tertiary structure. The cloverleaf structure is formed by the folding of the single-stranded tRNA molecule, which is typically ...

1 Department of Radiation Oncology, Cheeloo College of Medicine, Qilu Hospital of Shandong University, Shandong University, Jinan, Shandong, China 2 Research Center for Basic Medical Sciences, Qilu ...

Aminoacyl-tRNA synthetases (aaRS) catalyze the first step of protein synthesis by attaching amino acids to tRNAs. During this key step, aminoacyl-tRNA synthetases further ensure the correct ...

Just as space holds infinite mysteries, when we zoom in at the level of biomolecules (one trillion times smaller than a meter), there is still so much to learn. Rensselaer Polytechnic Institute's ...

Mycoplasma leucyl-tRNA synthetases (LeuRSs) have been identified in which the connective polypeptide 1 (CP1) amino acid editing domain that clears mischarged tRNAs are missing (Mycoplasma mobile) or ...