BMJ Evidence-Based Medicine

Reporting GUideline for Intervention DEscription in Rehabilitation (GUIDE-Rehab): a tool to open the ‘black box’ of rehabilitation complex interventions

In 2023, the World Health Assembly adopted a resolution to strengthen rehabilitation within health systems, calling for ...
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How good is the evidence to support primary care practice?

Correspondence to Dr Mark H Ebell, Department of Epidemiology and Biostatistics, College of Public Health, University of Georgia, 125 Miller Hall, UGA Health Sciences Campus, Athens, GA 30602, USA; ...
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Current knowledge on the adaptation of clinical practice guidelines: a scoping review

Background The adaptation of clinical practice guidelines (CPGs) is increasingly used to efficiently develop contextualised recommendations for local, regional and national settings. However, ...
Opinion
BMJ Evidence-Based MedicineOpinion

Ataluren for Duchenne: how politics and social pressure undermined evidence-based decisions

Last 28 March 2025, the European Commission decided not to renew the conditional marketing authorisation for Translarna (ataluren) in Duchenne’s disease due to lack of efficacy after 11 years in the ...
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Regression to the mean: a primer for evidence-based medicine practitioners

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Online First

Toward automating GRADE classification: a proof-of-concept evaluation of an artificial intelligence-based tool for semiautomated evidence quality rating in systematic reviews ...
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Less is more - but for whom? Evaluating patient reported outcomes in de-implementation

All over the world, patients receive healthcare that has little to no benefit, also called low-value care. There have been an increasing number of initiatives to reduce, or de-implement, low-value ...
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Potential risks of GenAI on medical education

Generative artificial intelligence (AI) moved from an experimental novelty into mainstream use as an everyday tool in under 3 years. Large language models (LLMs) now pass portions of knowledge ...
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Methodological quality and synthesis of case series and case reports

Correspondence to Dr Mohammad Hassan Murad, Evidence-Based Practice Center, Mayo Clinic, Rochester, MN 55905, USA; murad.mohammad{at}mayo.edu In 1904, Dr James Herrick evaluated a 20-year-old patient ...
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Count outcomes, rate ratios and rate differences

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Dietary Recommendations for Familial Hypercholesterolaemia: an Evidence-Free Zone

We have evaluated dietary recommendations for people diagnosed with familial hypercholesterolaemia (FH), a genetic condition in which increased low-density lipoprotein cholesterol (LDL-C) is ...
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Rapid reviews methods series: guidance on rapid qualitative evidence synthesis

This paper forms part of a series of methodological guidance from the Cochrane Rapid Reviews Methods Group and addresses rapid qualitative evidence syntheses (QESs), which use modified systematic, ...